The Chemotherapy+ Foundation is supporting Dr. Iavarone’s study of the link between stem/progenitor cells with cancer stem cells in the nervous system. Their findings show that transcription factors establish interconnected networks that start and maintain a defined tumor phenotype. Reconstruction of those networks in normal cells appears to be sufficient to confer the malignant properties associated with that phenotype. Their long-term goal is to understand the signaling systems involved in initiating and maintaining pediatric brain tumors. This could lead to identifying new targets for pediatric brain tumor therapy.